Hmmmm, this is an interesting topic. I have had the opportunity to have a skin before and have always passed on it. The problem is that you need a large amount of marketing dollars to get started and be successful. Even then with a skin you are still only making around 70% and have to cover guaranteed tournies and bonuses.
Unless you can drive massive players, it sometimes makes more sense just to negotiate a killer MGR deal.
On the flipside of that however, if I were going to do some sort of group project, it would be a casino for sure. Liquidity is not as important.
To enter the online poker market now you will either need a ton of money or a great niche to focus on. If anyone reading this wants to invest a couple million though, please inquire within.
